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Struggling with messy PCR gels? "Shadow bands" and "stutter products" can ruin your genotyping data and waste days of lab work. Whether it's polymerase slippage in microsatellites or simple contamination in your master mix, the fix is often simpler than you think. From switching to "Proofreading" enzyme blends to the "Low-Temp Denaturation" trick, we’ve compiled the ultimate scientific guide to cleaning up your PCR. Stop guessing and start getting publication-quality bands to

Seeing an unexpected band in your PCR negative control (NTC) is a frustrating problem that invalidates your results. But what does it mean? This article dives deep into the two most likely culprits: DNA contamination and primer-dimers. Explore contamination from reagents, equipment, or even the air can introduce unwanted DNA, and why your primers might be binding to each other. Most importantly, we provide a step-by-step action plan to decontaminate your workspace and get cle