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Is a RIN score below 7 the end of the road for your sequencing project? Not necessarily. While the "Gold Standard" of RIN > 8 is ideal for Illumina PolyA sequencing, modern techniques have rewritten the rules. From microRNA stability to Ribodepletion strategies for ancient samples, this article explores how to salvage data from degraded RNA. Learn why the RIN 7 cutoff is a myth for certain applications and discover the top 10 ways to improve your RNA isolation before you even