Discover the Latest in Biomedical Research Innovation

Stop doing math in the lab! Our Ultimate Guide to Hemocytometer Cell Counting breaks down the gold-standard protocol for accuracy and integrates CLYTE’s Free Biomedical Calculators to automate your seeding recipes. Whether you're tracking Doubling Time or seeding 96-well plates, this guide ensures your data is reproducible and error-free. Master the "Newton's Rings" technique and ditch the scratch-pad calculations today.

Struggling with ELISA results? You might be a victim of the "Hook Effect." It’s the paradox where too much target protein creates a false negative signal, destroying your data. Don't panic—the fix is often as simple as a paradoxical dilution. Our Ultimate Guide covers the difference between Prozone and Hook effects, why One-Step assays are vulnerable, and the exact Two-Step protocol to save your experiment. Stop throwing away positive samples!

Are you planning a pre-clinical study but struggling with the statistics? Determining the correct sample size is the single most critical step to ensure your biomedical research is ethical, economic, and publishable. In this detailed guide, we break down how to use G*Power, the industry-standard free software. From understanding Alpha and Beta errors to a step-by-step tutorial on t-tests for drug efficacy, we provide everything you need to justify your sample size in your nex

Stop drowning in data and start building a case. Most preclinical failures aren't technical—they're architectural. Discover why "Evidence Architecture" is the missing framework your biotech needs to survive FDA scrutiny, and hear about the rumored AI breakthrough from CLYTE that could change the game forever.

Stop guessing your cell seeding densities! Consistent experiments start with accurate cell growth kinetics. This guide breaks down the "Cell Doubling Time" formula, explains why it matters for reproducibility, and provides a step-by-step protocol for measuring it. We also introduce the CLYTE Cell Doubling Calculator—a free tool that automates the math so you can hit perfect confluency every time. Master your culture conditions and eliminate experimental drift today.

High background absorbance in MTT assays can ruin weeks of research, often caused by chemical interference, serum precipitation, or microbial contamination. This guide dives into the "purple haze" of false signals, offering expert troubleshooting tips—from using proper background controls to swapping media—to ensure your OD readings reflect true cellular health. Discover how to refine your protocol and when to switch to alternative assays.

Stop wasting hours on manual lab math! Discover the ultimate guide to CLYTE’s free Biomedical Research Calculators. From automating cell seeding recipes and calculating IC50/EC50 values to generating linear regression standard curves, this suite streamlines your workflow. Learn how to eliminate calculation errors and boost experimental reproducibility today.

Is a RIN score below 7 the end of the road for your sequencing project? Not necessarily. While the "Gold Standard" of RIN > 8 is ideal for Illumina PolyA sequencing, modern techniques have rewritten the rules. From microRNA stability to Ribodepletion strategies for ancient samples, this article explores how to salvage data from degraded RNA. Learn why the RIN 7 cutoff is a myth for certain applications and discover the top 10 ways to improve your RNA isolation before you even

2025 was the year CLYTE evolved from a hardware startup into a biomedical platform. From validating the CytCut device to launching Sophie AI, we achieved ~50k monthly visitors and 5 million impressions with extreme capital efficiency. Discover how we uncovered a massive market gap in lab protocols and secured our place in the future of lab automation.

From antioxidant vitamins and plant flavonoids that mimic cell activity to porphyrins that destroy the signal, many common compounds can skew your data, leading to false positives or negatives. This article explores the specific chemicals that disrupt tetrazolium assays, explains the mechanisms behind these artifacts, and provides essential best practices to ensure your cytotoxicity data is accurate and reproducible.

Are inclusion bodies the bane of your existence or a hidden opportunity? For researchers working with recombinant proteins in E. coli, finding your target protein in an insoluble pellet is a common frustration. But science shows these aggregates are specific, reversible, and often highly pure. This article dives into the mechanisms of protein aggregation, offers proven strategies to prevent it, and provides a step-by-step guide to solubilizing and refolding your protein for m

Scientific research has a plastic problem. Every year, laboratories perform an estimated 3 million "scratch assays" using disposable pipette tips, generating around 200 tons of contaminated plastic waste that cannot be recycled. CytCut offers a solution: a reusable device that eliminates this waste at the source. By replacing single-use tips and improving experimental reproducibility, CytCut cuts carbon footprints by up to 11-fold, proving that science can be rigorous without

Master the MTT assay with this comprehensive guide designed for accuracy and reproducibility. We break down the complex cell viability protocol into actionable steps, focusing on Primary Human Dermal Fibroblasts. Learn how to seed 10,000 cells/well, prepare 6 distinct product concentrations, and precisely measure metabolic activity using formazan detection at 540 nm.

Are you struggling to choose between the cost-effective MTT assay and the visually striking Live/Dead fluorescence staining? This guide breaks down the science, mechanisms, and pros and cons of the two most popular cell viability methods. Whether you are running high-throughput drug screenings or analyzing complex 3D spheroids, understanding the difference between metabolic activity and membrane integrity is key. Dive in to discover which assay reigns supreme for your specifi

CLYTE has officially joined the Google for Startups Cloud Program, a major milestone that validates its proprietary Sophie AI technology. This partnership grants CLYTE access to Google’s advanced computational resources, accelerating the release of Sophie 3.0 in January 2026. With enhanced reliability and deep-context analysis, CLYTE is redefining lab automation. The move sets the stage for a Q1 2026 Seed Round, signaling to investors that CLYTE’s tech stack is scalable and s

Discover how CLYTE is transforming biomedical research by aligning with the UN Sustainable Development Goals. From replacing disposable pipette tips with the reusable CytCut device (SDG 12) to democratizing access to the Soφ AI assistant (SDG 4), CLYTE is building a smarter, more sustainable future for science. Read how their specific innovations are solving the reproducibility crisis and driving global health progress.

Stop wasting time and money on endless minipreps! Colony PCR is the ultimate lab hack for molecular cloning, allowing you to rapidly screen bacterial or yeast colonies for your desired DNA insert in just a few hours. This definitive guide cuts through the noise and provides a detailed, step-by-step protocol for success. We dive deep into the one step most scientists get wrong—cell lysis and reveal primer design strategies!

This frustrating (and common) problem can ruin days of work, but the fix is often simple. Our comprehensive troubleshooting guide diagnoses the real reason for your patchy bands. We cover everything from the #1 culprit—air bubbles in your transfer sandwich—to aggregated antibodies, uneven gel polymerization, and improper sample prep. Stop guessing and start fixing. This article provides clear, actionable solutions to rescue your blot and get the clean, sharp bands you need.

Is your Western Blot showing a band at the wrong molecular weight? This is one of the most common frustrations in the lab, but it's not a dead end. An unexpected band size is often a critical clue, not a failed experiment. The theoretical calculated weight from amino acid sequence rarely matches the observed weight on a gel. This discrepancy can be caused by a host of biological reasons from post-translational modifications like glycosylation to protein cleavage, splice varia

Unlock the power of your clinical data with the Box and Whisker Plot! Learn the definitive step-by-step method for calculating the five-number summary—Min, Q1, Median, Q3, Max—and visualizing data distribution. From identifying critical outliers using the 1.5 x IQR rule to comparing drug efficacy in biomedical research, this guide is your key to superior data visualization that ranks and informs. Stop relying on means alone. Start seeing your data's true spread!